PhD student position “Novel Key Regulators of Glucocorticoid Receptor Action in Osteoporosis”
The Tuckermann Lab at the Instiute for General Zoology and Endocrinology/Ulm University (Director: Prof. Dr. Jan Tuckermann) is looking for a PhD student studying molecular mechanisms of glucocorticoid receptor actions in bone integrity in vivo.
Glucocorticoid hormones such as cortisone are potent anti-inflammatory drugs and are therefore widely used to treat inflammatory and autoimmune diseases. But the usefulness of glucocorticoid therapy is hampered by severe side effects such as diabetes and osteoporosis. In particular osteoporosis is becoming one of the most prevalent diseases in the ageing society. Our research interests focus on the cellular and molecular mechanisms of the glucocorticoid receptor (GR) underlying the beneficial and the adverse glucocorticoid actions in inflammation, metabolism and osteoporosis (PNAS (2011) 108:19317, Cell Metabolism (2010) 11:517, Nature Reviews Rheumatol (2012) 8:654), Mol Cell Endocrinol (2013) 380:108).
We identified novel hithero unknown regulatory genes of bone formation that are involved in GR action on bone mass and thus provide potential new drug targets to combat osteoporosis.
The project consists of in-depth analysis of these novel regulators in primary human and murine mesenchymal stem cells and bone cells as well as in transgenic mouse models in vivo. It involves a broad range of state-of-the-art techniques: cell biological, molecular biological techniques, viral gene delivery as well as histological methods, lineage tracing and micro computer tomography measurements in conditional knock out mice.
The successful candidate has a broad knowledge in molecular biology and a genuine interest in understanding molecular mechanisms of differentiation processes involved in organ integrity using in vivo approaches in transgenic mouse models. Furthermore experiences in molecular and cell biological methods are appreciated. We expect a highly motivated ambitious student ready for scientific challenges in this project relevant for osteoporosis affecting an ageing society.
We offer an enthusiastic international team and the possibility to join the International Graduate School in Molecular Medicine in Ulm with courses in state-of-the-art techniques and soft skills and support for conference visits.
The reistricted position starts from October 1st 2014 on a salary level according to TVLE13 (50%). The PhD position will be initially restricted for 2 years with a possibility for extension.
Applicants are invited to apply by sending a letter of interest, CV and contact details of two referees in a single PDF file by
email. latest August 30th 2014.
Please indicate the index number 55 in the subject line. Prof. Dr. Jan Tuckermann, Institute of General Zoology and Endocrinology, Ulm University, 89069 Ulm
Further information about the lab can be found at our homepage
Physically disabled applicants receive favourable consideration when equally qualified. The appointment is made by the central university administration.